Direct Binding of Integrin αvβ3 to FGF1 Plays a Role in FGF1 Signaling

Integrins play a role in fibroblast growth factor (FGF) signaling through cross-talk with FGF receptors (FGFRs), but the mechanism underlying the cross-talk is unknown. We discovered that FGF1 directly bound to soluble and cell-surface integrin αvβ3 (K(D) about 1 μm). Antagonists to αvβ3 (monoclonal...

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Bibliografiske detaljer
Main Authors: Mori, Seiji, Wu, Chun-Yi, Yamaji, Satoshi, Saegusa, Jun, Shi, Biao, Ma, Zi, Kuwabara, Yasuko, Lam, Kit S., Isseroff, R. Rivkah, Takada, Yoko K., Takada, Yoshikazu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440593/
https://ncbi.nlm.nih.gov/pubmed/18441324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801213200
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