The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis

We recently found that integrin αvβ3 binds to fibroblast growth factor (FGF)-αvβ31 (FGF1), and that the integrin-binding defective FGF1 mutant (Arg-50 to glutamic acid, R50E) is defective in signalling and antagonistic to FGF1 signalling. R50E suppressed angiogenesis and tumour growth, suggesting th...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Mori, Seiji, Hatori, Nobuaki, Kawaguchi, Naomasa, Hamada, Yoshinosuke, Shih, Tsung-Chieh, Wu, Chun-Yi, Lam, Kit S., Matsuura, Nariaki, Yamamoto, Hirofumi, Takada, Yoko K., Takada, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482197/
https://ncbi.nlm.nih.gov/pubmed/28302677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20170173
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