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Direct Binding of Integrin αvβ3 to FGF1 Plays a Role in FGF1 Signaling
Integrins play a role in fibroblast growth factor (FGF) signaling through cross-talk with FGF receptors (FGFRs), but the mechanism underlying the cross-talk is unknown. We discovered that FGF1 directly bound to soluble and cell-surface integrin αvβ3 (K(D) about 1 μm). Antagonists to αvβ3 (monoclonal...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440593/ https://ncbi.nlm.nih.gov/pubmed/18441324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801213200 |
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