Cross-talk between Integrin α6β4 and Insulin-like Growth Factor-1 Receptor (IGF1R) through Direct α6β4 Binding to IGF1 and Subsequent α6β4-IGF1-IGF1R Ternary Complex Formation in Anchorage-independent Conditions

Integrin αvβ3 plays a role in insulin-like growth factor-1 (IGF1) signaling (integrin-IGF1 receptor (IGF1R) cross-talk). The specifics of the cross-talk are, however, unclear. In a current model, “ligand occupancy” of αvβ3 (i.e. the binding of extracellular matrix proteins) enhances signaling induce...

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Detalhes bibliográficos
Main Authors: Fujita, Masaaki, Ieguchi, Katsuaki, Davari, Parastoo, Yamaji, Satoshi, Taniguchi, Yukimasa, Sekiguchi, Kiyotoshi, Takada, Yoko K., Takada, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320998/
https://ncbi.nlm.nih.gov/pubmed/22351760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304170
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