An Integrin Binding-defective Mutant of Insulin-like Growth Factor-1 (R36E/R37E IGF1) Acts as a Dominant-negative Antagonist of the IGF1 Receptor (IGF1R) and Suppresses Tumorigenesis but Still Binds to IGF1R

Insulin-like growth factor-1 (IGF1) is a major therapeutic target for cancer. We recently reported that IGF1 directly binds to integrins (αvβ3 and α6β4) and induces ternary complex formation (integrin-IGF1-IGF1 receptor (IGF1R)) and that the integrin binding-defective mutant of IGF1 (R36E/R37E) is d...

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Main Authors: Fujita, Masaaki, Ieguchi, Katsuaki, Cedano-Prieto, Dora M., Fong, Andrew, Wilkerson, Charles, Chen, Jane Q., Wu, Mac, Lo, Su-Hao, Cheung, Anthony T. W., Wilson, Machelle D., Cardiff, Robert D., Borowsky, Alexander D., Takada, Yoko K., Takada, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707660/
https://ncbi.nlm.nih.gov/pubmed/23696648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470872
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