Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Matveeva, Olga V., Kang, Yibin, Spiridonov, Alexey N., Sætrom, Pål, Nemtsov, Vladimir A., Ogurtsov, Aleksey Y., Nechipurenko, Yury D., Shabalina, Svetlana A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857877/
https://ncbi.nlm.nih.gov/pubmed/20422034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010180
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires