Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...

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Detalhes bibliográficos
Main Authors: Matveeva, Olga V., Kang, Yibin, Spiridonov, Alexey N., Sætrom, Pål, Nemtsov, Vladimir A., Ogurtsov, Aleksey Y., Nechipurenko, Yury D., Shabalina, Svetlana A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857877/
https://ncbi.nlm.nih.gov/pubmed/20422034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010180
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