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Inactivation of HAUSP in vivo modulates p53 function
Hausp is a deubiquitinase that has been shown to regulate the p53–Mdm2 pathway. Cotransfection of p53 and Hausp stabilizes p53 through the removal of ubiquitin moieties from polyubiquitinated p53. Interestingly, knockout or RNA interference-mediated knockdown of Hausp in human cells also resulted in...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857765/ https://ncbi.nlm.nih.gov/pubmed/19946331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.427 |
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