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Modulation of the p53/MDM2 interplay by HAUSP inhibitors
It is well established that both p53 and MDM2 are short-lived proteins whose stabilities are tightly controlled through ubiquitination-mediated degradation. Although numerous studies indicate that the MDM2 E3 ligase activity, as well as the protein–protein interaction between p53 and MDM2, is the ma...
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| Publicado no: | J Mol Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310345/ https://ncbi.nlm.nih.gov/pubmed/27927749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjw049 |
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