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The p53–Mdm2–HAUSP complex is involved in p53 stabilization by HAUSP
The ubiquitin-specific protease HAUSP is a critical component of the p53–Mdm2 pathway by acting as a specific deubiquitinase for both p53 and Mdm2. Recent structural studies have indicated that p53 and Mdm2 bind to the N-terminal TRAF-like domain of HAUSP in a mutually exclusive manner. To understan...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690499/ https://ncbi.nlm.nih.gov/pubmed/17525743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210531 |
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