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The p53–Mdm2–HAUSP complex is involved in p53 stabilization by HAUSP

The ubiquitin-specific protease HAUSP is a critical component of the p53–Mdm2 pathway by acting as a specific deubiquitinase for both p53 and Mdm2. Recent structural studies have indicated that p53 and Mdm2 bind to the N-terminal TRAF-like domain of HAUSP in a mutually exclusive manner. To understan...

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Bibliografiske detaljer
Main Authors: Brooks, CL, Li, M, Hu, M, Shi, Y, Gu, W
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690499/
https://ncbi.nlm.nih.gov/pubmed/17525743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210531
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