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HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response

HAUSP (herpes virus-associated ubiquitin specific protease, known as ubiquitin specific protease 7), one of DUBs, regulates the dynamics of the p53 and Mdm2 network in response to DNA damage by deubiquitinating both p53 and its E3 ubiquitin ligase, Mdm2. Its concerted action increases the level of f...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Lim, Key-Hwan, Park, Jang-Joon, Gu, Bon-Hee, Kim, Jin-Ock, Park, Sang Gyu, Baek, Kwang-Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523935/
https://ncbi.nlm.nih.gov/pubmed/26238070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12793
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