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HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response

HAUSP (herpes virus-associated ubiquitin specific protease, known as ubiquitin specific protease 7), one of DUBs, regulates the dynamics of the p53 and Mdm2 network in response to DNA damage by deubiquitinating both p53 and its E3 ubiquitin ligase, Mdm2. Its concerted action increases the level of f...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Lim, Key-Hwan, Park, Jang-Joon, Gu, Bon-Hee, Kim, Jin-Ock, Park, Sang Gyu, Baek, Kwang-Hyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523935/
https://ncbi.nlm.nih.gov/pubmed/26238070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12793
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