Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function

Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the cell cycle, it is expected the development of a potent, selective small molecule inh...

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Autori principali: Kwiatkowski, Nicholas, Jelluma, Nannette, Filippakopoulos, Panagis, Soundararajan, Meera, Manak, Michael S., Kwon, Mijung, Choi, Hwan Geun, Sim, Taebo, Deveraux, Quinn L., Rottmann, Sabine, Pellman, David, Shah, Jagesh V., Kops, Geert J.P.L., Knapp, Stefan, Gray, Nathanael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857554/
https://ncbi.nlm.nih.gov/pubmed/20383151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.345
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