Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Degenhardt, Kurt, Mathew, Robin, Beaudoin, Brian, Bray, Kevin, Anderson, Diana, Chen, Guanghua, Mukherjee, Chandreyee, Shi, Yufang, Gélinas, Céline, Fan, Yongjun, Nelson, Deirdre A., Jin, Shengkan, White, Eileen
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857533/
https://ncbi.nlm.nih.gov/pubmed/16843265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.06.001
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki