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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2006
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857533/ https://ncbi.nlm.nih.gov/pubmed/16843265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.06.001 |
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