Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by...

Full description

Saved in:
Bibliographic Details
Main Authors: Degenhardt, Kurt, Mathew, Robin, Beaudoin, Brian, Bray, Kevin, Anderson, Diana, Chen, Guanghua, Mukherjee, Chandreyee, Shi, Yufang, Gélinas, Céline, Fan, Yongjun, Nelson, Deirdre A., Jin, Shengkan, White, Eileen
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857533/
https://ncbi.nlm.nih.gov/pubmed/16843265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.06.001
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items