Human DNA methylomes at base resolution show widespread epigenomic differences

DNA cytosine methylation is a central epigenetic modification that plays essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base resolution maps of methylated cytosines in a mammalian genome, from both human embry...

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Autori principali: Lister, Ryan, Pelizzola, Mattia, Dowen, Robert H., Hawkins, R. David, Hon, Gary, Tonti-Filippini, Julian, Nery, Joseph R., Lee, Leonard, Ye, Zhen, Ngo, Que-Minh, Edsall, Lee, Antosiewicz-Bourget, Jessica, Stewart, Ron, Ruotti, Victor, Millar, A. Harvey, Thomson, James A., Ren, Bing, Ecker, Joseph R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857523/
https://ncbi.nlm.nih.gov/pubmed/19829295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08514
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