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Reduced seed region-based off-target activity with lentivirus-mediated RNAi
Along with silencing intended target genes, transfected siRNAs regulate numerous unintended transcripts through a mechanism in which the equivalent of a microRNA-like seed region in the siRNA recognizes complementary sequences in transcript 3′ UTRs. Amelioration of this off-target silencing would le...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856882/ https://ncbi.nlm.nih.gov/pubmed/20348445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1977810 |
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