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DISE - A Seed Dependent RNAi Off-Target Effect that Kills Cancer Cells
Off-target effects (OTE) present a significant caveat of RNA interference (RNAi) caused by substantial complementarity between small interfering (si)RNAs and unintended mRNAs. We now discuss the existence of three types of seed dependent (s)OTEs: Type I involves unintended targeting through the guid...
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| Publicado no: | Trends Cancer |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5806146/ https://ncbi.nlm.nih.gov/pubmed/29413418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2017.11.007 |
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