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The Effects of PKCα Phosphorylation on the Extensibility of Titin’s PEVK Element

Posttranslational modifications, along with isoform splicing, of titin determine the passive tension development of stretched sarcomeres. It was recently shown that PKCα phosphorylates two highly-conserved residues (S26 and S170) of the PEVK region in cardiac titin, resulting in passive tension incr...

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Main Authors: Anderson, Brian R., Bogomolovas, Julius, Labeit, Siegfried, Granzier, Henk
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856808/
https://ncbi.nlm.nih.gov/pubmed/20149875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2010.02.002
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