An Achilles' Heel in an Amyloidogenic Protein and Its Repair: INSULIN FIBRILLATION AND THERAPEUTIC DESIGN

Insulin fibrillation provides a model for a broad class of amyloidogenic diseases. Conformational distortion of the native monomer leads to aggregation-coupled misfolding. Whereas β-cells are protected from proteotoxicity by hexamer assembly, fibrillation limits the storage and use of insulin at ele...

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Detalhes bibliográficos
Main Authors: Yang, Yanwu, Petkova, Aneta, Huang, Kun, Xu, Bin, Hua, Qing-xin, Ye, I-Ju, Chu, Ying-Chi, Hu, Shi-Quan, Phillips, Nelson B., Whittaker, Jonathan, Ismail-Beigi, Faramarz, Mackin, Robert B., Katsoyannis, Panayotis G., Tycko, Robert, Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856287/
https://ncbi.nlm.nih.gov/pubmed/20106984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067850
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