High Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites

Por Whittaker, Linda, Hao, Caili, Fu, Wen, Whittaker, Jonathan
Publicado em 2008

Insulin Fibrillation and Protein Design: Topological Resistance of Single-Chain Analogs to Thermal Degradation with Application to a Pump Reservoir

Por Phillips, Nelson B., Whittaker, Jonathan, Ismail-Beigi, Faramarz, Weiss, Michael A.
Publicado em 2012

Deciphering a Molecular Mechanism of Neonatal Diabetes Mellitus by the Chemical Synthesis of a Protein Diastereomer, [d-Ala(B8)]Human Proinsulin

Por Avital-Shmilovici, Michal, Whittaker, Jonathan, Weiss, Michael A., Kent, Stephen B. H.
Publicado em 2014

Precise mapping of an IGF-I-binding site on the IGF-1R

Por Keyhanfar, Mehrnaz, Booker, Grant W., Whittaker, Jonathan, Wallace, John C., Forbes, Briony E.
Publicado em 2006

The Structure of a Mutant Insulin Uncouples Receptor Binding from Protein Allostery: AN ELECTROSTATIC BLOCK TO THE TR TRANSITION

Por Wan, Zhu-li, Huang, Kun, Hu, Shi-Quan, Whittaker, Jonathan, Weiss, Michael A.
Publicado em 2008

Design and Folding of [Glu(A4)(O(β)Thr(B30))]Insulin (‘Ester Insulin’), a Minimal Proinsulin Surrogate Chemically Convertible to Human Insulin

Por Sohma, Youhei, Hua, Qing-Xin, Whittaker, Jonathan, Weiss, Michael A., Kent, Stephen B. H.
Publicado em 2010

Contribution of Tyr(B26) to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE

Por Pandyarajan, Vijay, Phillips, Nelson B., Rege, Nischay, Lawrence, Michael C., Whittaker, Jonathan, Weiss, Michael A.
Publicado no J Biol Chem (2016)

Efficient Total Chemical Synthesis of (13)C=(18)O Isotopomers of Human Insulin for Isotope-Edited FTIR

Por Dhayalan, Balamurugan, Fitzpatrick, Ann, Mandal, Kalyaneswar, Whittaker, Jonathan, Weiss, Michael A., Tokmakoff, Andrei, Kent, Stephen B. H.
Publicado no Chembiochem (2016)

Biophysical Optimization of a Therapeutic Protein by Nonstandard Mutagenesis: STUDIES OF AN IODO-INSULIN DERIVATIVE

Por Pandyarajan, Vijay, Phillips, Nelson B., Cox, Gabriela P., Yang, Yanwu, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Weiss, Michael A.
Publicado em 2014

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

Por Whittaker, Jonathan, Whittaker, Linda J., Roberts, Charles T., Phillips, Nelson B., Ismail-Beigi, Faramarz, Lawrence, Michael C., Weiss, Michael A.
Publicado em 2012

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

Por Croll, Tristan I., Smith, Brian J., Margetts, Mai B., Whittaker, Jonathan, Weiss, Michael A., Ward, Colin W., Lawrence, Michael C.
Publicado no Structure (2016)

Deciphering the Hidden Informational Content of Protein Sequences: FOLDABILITY OF PROINSULIN HINGES ON A FLEXIBLE ARM THAT IS DISPENSABLE IN THE MATURE HORMONE

Por Liu, Ming, Hua, Qing-xin, Hu, Shi-Quan, Jia, Wenhua, Yang, Yanwu, Saith, Sunil Evan, Whittaker, Jonathan, Arvan, Peter, Weiss, Michael A.
Publicado em 2010

A Novel Approach to Identify Two Distinct Receptor Binding Surfaces of Insulin-like Growth Factor II

Por Alvino, Clair L., McNeil, Kerrie A., Ong, Shee Chee, Delaine, Carlie, Booker, Grant W., Wallace, John C., Whittaker, Jonathan, Forbes, Briony E.
Publicado em 2009

Design of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

Por Zhao, Ming, Wan, Zhu-li, Whittaker, Linda, Xu, Bin, Phillips, Nelson B., Katsoyannis, Panayotis G., Ismail-Beigi, Faramarz, Whittaker, Jonathan, Weiss, Michael A.
Publicado em 2009

Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS

Por Hua, Qing-xin, Xu, Bin, Huang, Kun, Hu, Shi-Quan, Nakagawa, Satoe, Jia, Wenhua, Wang, Shuhua, Whittaker, Jonathan, Katsoyannis, Panayotis G., Weiss, Michael A.
Publicado em 2009

Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT

Por Phillips, Nelson B., Wan, Zhu-li, Whittaker, Linda, Hu, Shi-Quan, Huang, Kun, Hua, Qing-xin, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Weiss, Michael A.
Publicado em 2010

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY

Por El Hage, Krystel, Pandyarajan, Vijay, Phillips, Nelson B., Smith, Brian J., Menting, John G., Whittaker, Jonathan, Lawrence, Michael C., Meuwly, Markus, Weiss, Michael A.
Publicado no J Biol Chem (2016)

Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning: INSULIN INSERTS A DETACHABLE ARM BETWEEN RECEPTOR DOMAINS

Por Xu, Bin, Huang, Kun, Chu, Ying-Chi, Hu, Shi-Quan, Nakagawa, Satoe, Wang, Shuhua, Wang, Run-Ying, Whittaker, Jonathan, Katsoyannis, Panayotis G., Weiss, Michael A.
Publicado em 2009

Structural Basis of the Aberrant Receptor Binding Properties of Hagfish and Lamprey Insulins

Por Sajid, Waseem, Holst, Patricia A., Kiselyov, Vladislav V., Andersen, Asser S., Conlon, J. Michael, Kristensen, Claus, Kjeldsen, Thomas, Whittaker, Jonathan, Chan, Shu J., De Meyts, Pierre
Publicado em 2009

Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I: CONSTRAINTS AND FINE-TUNING IN THE EVOLUTION OF A PROTEIN FAMILY

Por Sohma, Youhei, Hua, Qing-xin, Liu, Ming, Phillips, Nelson B., Hu, Shi-Quan, Whittaker, Jonathan, Whittaker, Linda J., Ng, Aubree, Roberts, Charles T., Arvan, Peter, Kent, Stephen B. H., Weiss, Michael A.
Publicado em 2010