Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

Insulin receptor (IR) signaling is critical to controlling nutrient uptake and metabolism. However, only a low-resolution (3.8 Å) structure currently exists for the IR ectodomain, with some segments ill-defined or unmodeled due to disorder. Here, we revise this structure using new diffraction data t...

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Pubblicato in:Structure
Autori principali: Croll, Tristan I., Smith, Brian J., Margetts, Mai B., Whittaker, Jonathan, Weiss, Michael A., Ward, Colin W., Lawrence, Michael C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860004/
https://ncbi.nlm.nih.gov/pubmed/26853939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.12.014
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