Design of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

Insulin binds with high affinity to the insulin receptor (IR) and with low affinity to the type 1 insulin-like growth factor (IGF) receptor (IGFR). Such cross-binding, which reflects homologies within the insulin-IGF signaling system, is of clinical interest in relation to the association between hy...

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Detalhes bibliográficos
Main Authors: Zhao, Ming, Wan, Zhu-li, Whittaker, Linda, Xu, Bin, Phillips, Nelson B., Katsoyannis, Panayotis G., Ismail-Beigi, Faramarz, Whittaker, Jonathan, Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797288/
https://ncbi.nlm.nih.gov/pubmed/19773552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028399
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