Lanean...
An Achilles' Heel in an Amyloidogenic Protein and Its Repair: INSULIN FIBRILLATION AND THERAPEUTIC DESIGN
Insulin fibrillation provides a model for a broad class of amyloidogenic diseases. Conformational distortion of the native monomer leads to aggregation-coupled misfolding. Whereas β-cells are protected from proteotoxicity by hexamer assembly, fibrillation limits the storage and use of insulin at ele...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , , , |
|---|---|
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2010
|
| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856287/ https://ncbi.nlm.nih.gov/pubmed/20106984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067850 |
| Etiketak: |
Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
|