Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT

Bottom-up control of supramolecular protein assembly can provide a therapeutic nanobiotechnology. We demonstrate that the pharmacological properties of insulin can be enhanced by design of “zinc staples” between hexamers. Paired (i, i+4) His substitutions were introduced at an α-helical surface. The...

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Huvudupphovsmän: Phillips, Nelson B., Wan, Zhu-li, Whittaker, Linda, Hu, Shi-Quan, Huang, Kun, Hua, Qing-xin, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Weiss, Michael A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
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Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852910/
https://ncbi.nlm.nih.gov/pubmed/20181952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.105825
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