Supramolecular Protein Engineering: DESIGN OF ZINC-STAPLED INSULIN HEXAMERS AS A LONG ACTING DEPOT

Bottom-up control of supramolecular protein assembly can provide a therapeutic nanobiotechnology. We demonstrate that the pharmacological properties of insulin can be enhanced by design of “zinc staples” between hexamers. Paired (i, i+4) His substitutions were introduced at an α-helical surface. The...

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מידע ביבליוגרפי
Main Authors: Phillips, Nelson B., Wan, Zhu-li, Whittaker, Linda, Hu, Shi-Quan, Huang, Kun, Hua, Qing-xin, Whittaker, Jonathan, Ismail-Beigi, Faramarz, Weiss, Michael A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Reports
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852910/
https://ncbi.nlm.nih.gov/pubmed/20181952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.105825
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