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G-PROTEIN COUPLED RECEPTOR KINASES MEDIATE TNFα-INDUCED NFκB SIGNALING VIA DIRECT INTERACTION WITH AND PHOSPHORYLATION OF IκBα
Tumor necrosis factor-α (TNFα) is a multifunctional cytokine involved in the pathophysiology of many chronic inflammatory diseases. TNFα activation of the nuclear factor κB (NFκB) signaling pathway particularly in macrophages has been implicated in many diseases. We demonstrate here that G-protein c...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856098/ https://ncbi.nlm.nih.gov/pubmed/19796012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090908 |
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