NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
Activation of the transcription factor NF-κB by inflammatory cytokines involves the successive action of NF-κB-inducing kinase (NIK) and two IκB kinases, IKK-α and IKK-β. Here we show that NIK preferentially phosphorylates IKK-α over IKK-β, leading to the activation of IKK-α kinase activity. This ph...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19916/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3792 |
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