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NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
Activation of the transcription factor NF-κB by inflammatory cytokines involves the successive action of NF-κB-inducing kinase (NIK) and two IκB kinases, IKK-α and IKK-β. Here we show that NIK preferentially phosphorylates IKK-α over IKK-β, leading to the activation of IKK-α kinase activity. This ph...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The National Academy of Sciences
1998
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC19916/ https://ncbi.nlm.nih.gov/pubmed/9520446 |
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