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NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

Activation of the transcription factor NF-κB by inflammatory cytokines involves the successive action of NF-κB-inducing kinase (NIK) and two IκB kinases, IKK-α and IKK-β. Here we show that NIK preferentially phosphorylates IKK-α over IKK-β, leading to the activation of IKK-α kinase activity. This ph...

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Autori principali: Ling, Lei, Cao, Zhaodan, Goeddel, David V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC19916/
https://ncbi.nlm.nih.gov/pubmed/9520446
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