RSK2 mediates NF-κB activity through the phosphorylation of IκBα in the TNF-R1 pathway

The ribosomal S6 kinase 2 (RSK2) is a well-known serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins. It is activated downstream of the MEK/ERKs cascade by mitogenic stimuli such as EGF or TPA. Here, we show that RSK2 is activated by treatment with tumor n...

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Hlavní autoři: Peng, Cong, Cho, Yong-Yeon, Zhu, Feng, Xu, Yan-Ming, Wen, Weihong, Ma, Wei-Ya, Bode, Ann M., Dong, Zigang
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2010
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923348/
https://ncbi.nlm.nih.gov/pubmed/20385620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-151290
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