Phosphorylation of Caspase-8 (Thr-263) by Ribosomal S6 Kinase 2 (RSK2) Mediates Caspase-8 Ubiquitination and Stability

The ribosomal S6 kinase 2 (RSK2) is a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins and plays a critical role in proliferation, cell cycle, and cell transformation. Here, we report that RSK2 phosphorylates caspase-8, and Thr-263 was identified as a novel caspase-8 phosphorylation...

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Detalhes bibliográficos
Main Authors: Peng, Cong, Cho, Yong-Yeon, Zhu, Feng, Zhang, Jishuai, Wen, Weihong, Xu, Yanming, Yao, Ke, Ma, Wei-Ya, Bode, Ann M., Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044950/
https://ncbi.nlm.nih.gov/pubmed/21183680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172338
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