Phosphorylation of Caspase-7 by p21-activated Protein Kinase (PAK) 2 Inhibits Chemotherapeutic Drug-induced Apoptosis of Breast Cancer Cell Lines

p21-activated kinase (PAK) 2, a member of the PAK family of serine/threonine protein kinases, plays an important role in physiological processes such as motility, survival, mitosis, and apoptosis. However, the role of PAK2 in resistance to chemotherapy is unclear. Here we report that PAK2 is highly...

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Detalhes bibliográficos
Main Authors: Li, Xiang, Wen, Weihong, Liu, Kangdong, Zhu, Feng, Malakhova, Margarita, Peng, Cong, Li, Tingting, Kim, Hong-Gyum, Ma, Weiya, Cho, Yong Yeon, Bode, Ann M., Dong, Ziming, Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121375/
https://ncbi.nlm.nih.gov/pubmed/21555521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236596
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