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G-PROTEIN COUPLED RECEPTOR KINASES MEDIATE TNFα-INDUCED NFκB SIGNALING VIA DIRECT INTERACTION WITH AND PHOSPHORYLATION OF IκBα

Tumor necrosis factor-α (TNFα) is a multifunctional cytokine involved in the pathophysiology of many chronic inflammatory diseases. TNFα activation of the nuclear factor κB (NFκB) signaling pathway particularly in macrophages has been implicated in many diseases. We demonstrate here that G-protein c...

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書誌詳細
主要な著者: Patial, Sonika, Luo, Jiansong, Porter, Katie J., Benovic, Jeffrey L., Parameswaran, Narayanan
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856098/
https://ncbi.nlm.nih.gov/pubmed/19796012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090908
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