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G-PROTEIN COUPLED RECEPTOR KINASES MEDIATE TNFα-INDUCED NFκB SIGNALING VIA DIRECT INTERACTION WITH AND PHOSPHORYLATION OF IκBα

Tumor necrosis factor-α (TNFα) is a multifunctional cytokine involved in the pathophysiology of many chronic inflammatory diseases. TNFα activation of the nuclear factor κB (NFκB) signaling pathway particularly in macrophages has been implicated in many diseases. We demonstrate here that G-protein c...

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Autori principali: Patial, Sonika, Luo, Jiansong, Porter, Katie J., Benovic, Jeffrey L., Parameswaran, Narayanan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856098/
https://ncbi.nlm.nih.gov/pubmed/19796012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090908
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