Efficient integration of transgenes into a defined locus in human embryonic stem cells

Random integration is one of the more straightforward methods to introduce a transgene into human embryonic stem (ES) cells. However, random integration may result in transgene silencing and altered cell phenotype due to insertional mutagenesis in undefined gene regions. Moreover, reliability of dat...

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Библиографические подробности
Главные авторы: Sakurai, Kenji, Shimoji, Miho, Tahimic, Candice G. T., Aiba, Kazuhiro, Kawase, Eihachiro, Hasegawa, Kouichi, Amagai, Yuji, Suemori, Hirofumi, Nakatsuji, Norio
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2010
Предметы:
Methods Online
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853137/
https://ncbi.nlm.nih.gov/pubmed/20071742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1234
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