Efficient integration of transgenes into a defined locus in human embryonic stem cells

Random integration is one of the more straightforward methods to introduce a transgene into human embryonic stem (ES) cells. However, random integration may result in transgene silencing and altered cell phenotype due to insertional mutagenesis in undefined gene regions. Moreover, reliability of dat...

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Detaylı Bibliyografya
Asıl Yazarlar: Sakurai, Kenji, Shimoji, Miho, Tahimic, Candice G. T., Aiba, Kazuhiro, Kawase, Eihachiro, Hasegawa, Kouichi, Amagai, Yuji, Suemori, Hirofumi, Nakatsuji, Norio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2010
Konular:
Methods Online
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853137/
https://ncbi.nlm.nih.gov/pubmed/20071742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1234
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