The ribosome assembly factor Nep1 responsible for Bowen–Conradi syndrome is a pseudouridine-N1-specific methyltransferase

Nep1 (Emg1) is a highly conserved nucleolar protein with an essential function in ribosome biogenesis. A mutation in the human Nep1 homolog causes Bowen–Conradi syndrome—a severe developmental disorder. Structures of Nep1 revealed a dimer with a fold similar to the SPOUT-class of RNA-methyltransfera...

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Autores principales: Wurm, Jan Philip, Meyer, Britta, Bahr, Ute, Held, Martin, Frolow, Olga, Kötter, Peter, Engels, Joachim W., Heckel, Alexander, Karas, Michael, Entian, Karl-Dieter, Wöhnert, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853112/
https://ncbi.nlm.nih.gov/pubmed/20047967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1189
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