The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site

Ribosome biogenesis in eukaryotes requires the participation of a large number of ribosome assembly factors. The highly conserved eukaryotic nucleolar protein Nep1 has an essential but unknown function in 18S rRNA processing and ribosome biogenesis. In Saccharomyces cerevisiae the malfunction of a t...

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Detalhes bibliográficos
Main Authors: Taylor, Alexander B., Meyer, Britta, Leal, Belinda Z., Kötter, Peter, Schirf, Virgil, Demeler, Borries, Hart, P. John, Entian, Karl-Dieter, Wöhnert, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275143/
https://ncbi.nlm.nih.gov/pubmed/18208838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1172
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