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The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site

Ribosome biogenesis in eukaryotes requires the participation of a large number of ribosome assembly factors. The highly conserved eukaryotic nucleolar protein Nep1 has an essential but unknown function in 18S rRNA processing and ribosome biogenesis. In Saccharomyces cerevisiae the malfunction of a t...

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Dettagli Bibliografici
Autori principali: Taylor, Alexander B., Meyer, Britta, Leal, Belinda Z., Kötter, Peter, Schirf, Virgil, Demeler, Borries, Hart, P. John, Entian, Karl-Dieter, Wöhnert, Jens
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275143/
https://ncbi.nlm.nih.gov/pubmed/18208838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1172
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