Characterization of the cofactor-binding site in the SPOUT-fold methyltransferases by computational docking of S-adenosylmethionine to three crystal structures

BACKGROUND: There are several evolutionarily unrelated and structurally dissimilar superfamilies of S-adenosylmethionine (AdoMet)-dependent methyltransferases (MTases). A new superfamily (SPOUT) has been recently characterized on a sequence level and three structures of its members (1gz0, 1ipa, and...

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izdano v:	BMC Bioinformatics
Principais autores:	Kurowski, Michal A, Sasin, Joanna M, Feder, Marcin, Debski, Janusz, Bujnicki, Janusz M
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2003
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12689347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2105-4-9
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