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Characterization of the cofactor-binding site in the SPOUT-fold methyltransferases by computational docking of S-adenosylmethionine to three crystal structures

BACKGROUND: There are several evolutionarily unrelated and structurally dissimilar superfamilies of S-adenosylmethionine (AdoMet)-dependent methyltransferases (MTases). A new superfamily (SPOUT) has been recently characterized on a sequence level and three structures of its members (1gz0, 1ipa, and...

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Detalhes bibliográficos
Main Authors: Kurowski, Michal A, Sasin, Joanna M, Feder, Marcin, Debski, Janusz, Bujnicki, Janusz M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153507/
https://ncbi.nlm.nih.gov/pubmed/12689347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-4-9
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