Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of chemical agents associated with marine algal blooms and shellfish toxicity. Analysis of 13-desmethyl spirolide C and gymnodimine A by binding and voltage-clamp recordings on muscle-type α1(2)βγδ and neuronal α3β2...

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Autores principales: Bourne, Yves, Radić, Zoran, Aráoz, Rómulo, Talley, Todd T., Benoit, Evelyne, Servent, Denis, Taylor, Palmer, Molgó, Jordi, Marchot, Pascale
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851920/
https://ncbi.nlm.nih.gov/pubmed/20224036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912372107
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