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Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Rα2
Interleukin-13 is a cytokine important for development of T-helper cell type 2 (Th2) responses and plays a critical role in asthma and allergy. The IL-13 Receptor α2 (IL-13Rα2) is a receptor for IL-13 lacking canonical Jak/STAT signaling functions. Here we present the crystal structure along with a...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850121/ https://ncbi.nlm.nih.gov/pubmed/20223216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.01.003 |
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