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Mutant APH(2″)-IIa Enzymes with Increased Activity against Amikacin and Isepamicin
Directed evolution by random PCR mutagenesis of the gene for the aminoglycoside 2″-IIa phosphotransferase generated R92H/D268N and N196D/D268N mutant enzymes, resulting in elevated levels of resistance to amikacin and isepamicin but not to other aminoglycoside antibiotics. Increases in the activitie...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849353/ https://ncbi.nlm.nih.gov/pubmed/20145089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01444-09 |
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