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Bulky “Gatekeeper” Residue Changes the Cosubstrate Specificity of Aminoglycoside 2″-Phosphotransferase IIa

The aminoglycoside 2″-phosphotransferases APH(2″)-IIa and APH(2″)-IVa can utilize ATP and GTP as cosubstrates, since both enzymes possess overlapping but discrete structural templates for ATP and GTP binding. APH(2″)-IIIa uses GTP exclusively, because its ATP-binding template is blocked by a bulky t...

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Detalhes bibliográficos
Main Authors: Bhattacharya, Monolekha, Toth, Marta, Smith, Clyde A., Vakulenko, Sergei B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719757/
https://ncbi.nlm.nih.gov/pubmed/23716051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00381-13
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