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Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2″-IVa
Acquired resistance to aminoglycoside antibiotics primarily results from deactivation by three families of aminoglycoside-modifying enzymes. Here, we report the kinetic mechanism and structure of the aminoglycoside phosphotransferase 2″-IVa (APH(2″)-IVa), an enzyme responsible for resistance to amin...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923509/ https://ncbi.nlm.nih.gov/pubmed/20556826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.437 |
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