Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2″-IVa

Acquired resistance to aminoglycoside antibiotics primarily results from deactivation by three families of aminoglycoside-modifying enzymes. Here, we report the kinetic mechanism and structure of the aminoglycoside phosphotransferase 2″-IVa (APH(2″)-IVa), an enzyme responsible for resistance to amin...

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Autores principales: Toth, Marta, Frase, Hilary, Antunes, Nuno Tiago, Smith, Clyde A, Vakulenko, Sergei B
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923509/
https://ncbi.nlm.nih.gov/pubmed/20556826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.437
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