Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia revealed by crystallographic and small-angle X-ray scattering analysis

Broad-spectrum resistance to aminoglycoside antibiotics in clinically important Gram-positive staphylococcal and entero­coccal pathogens is primarily conferred by the bifunctional enzyme AAC(6′)-Ie-APH(2′′)-Ia. This enzyme possesses an N-terminal coenzyme A-dependent acetyltransferase domain [AAC(6′...

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Hlavní autoři: Smith, Clyde A., Toth, Marta, Weiss, Thomas M., Frase, Hilary, Vakulenko, Sergei B.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2014
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188014/
https://ncbi.nlm.nih.gov/pubmed/25286858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714017635
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