Phospholemman Modulates the Gating of Cardiac L-Type Calcium Channels

Ca(2+) entry through L-type calcium channels (Ca(V)1.2) is critical in shaping the cardiac action potential and initiating cardiac contraction. Modulation of Ca(V)1.2 channel gating directly affects myocyte excitability and cardiac function. We have found that phospholemman (PLM), a member of the FX...

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Hlavní autoři: Wang, Xianming, Gao, Guofeng, Guo, Kai, Yarotskyy, Viktor, Huang, Congxin, Elmslie, Keith S., Peterson, Blaise Z.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2010
Témata:
Channels and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849072/
https://ncbi.nlm.nih.gov/pubmed/20371314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.11.032
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