Phospholemman Modulates the Gating of Cardiac L-Type Calcium Channels

Ca(2+) entry through L-type calcium channels (Ca(V)1.2) is critical in shaping the cardiac action potential and initiating cardiac contraction. Modulation of Ca(V)1.2 channel gating directly affects myocyte excitability and cardiac function. We have found that phospholemman (PLM), a member of the FX...

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Bibliographic Details
Main Authors: Wang, Xianming, Gao, Guofeng, Guo, Kai, Yarotskyy, Viktor, Huang, Congxin, Elmslie, Keith S., Peterson, Blaise Z.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2010
Subjects:
Channels and Transporters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849072/
https://ncbi.nlm.nih.gov/pubmed/20371314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.11.032
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