Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels

We have found that phospholemman (PLM) associates with and modulates the gating of cardiac L-type calcium channels (Wang et al., Biophys J 98: 1149–1159, 2010). The short 17 amino acid extracellular NH(2)-terminal domain of PLM contains a highly conserved PFTYD sequence that defines it as a member o...

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Detalhes bibliográficos
Main Authors: Guo, Kai, Wang, Xianming, Gao, Guofeng, Huang, Congxin, Elmslie, Keith S., Peterson, Blaise Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980306/
https://ncbi.nlm.nih.gov/pubmed/20720179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00149.2010
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