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A Single Amino Acid Change in Ca(V)1.2 Channels Eliminates the Permeation and Gating Differences between Ca(2+) versus Ba(2+)
Glutamate scanning mutagenesis was used to assess the role of the calcicludine binding segment in regulating channel permeation and gating using both Ca(2+) and Ba(2+) as charge carriers. As expected, wild-type L-type calcium channels had a Ba(2+) conductance ~2× that in Ca(2+) (G(Ba)/G(Ca) = 2) and...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3704197/ https://ncbi.nlm.nih.gov/pubmed/20098982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-009-9221-1 |
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