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A Single Amino Acid Change in Ca(V)1.2 Channels Eliminates the Permeation and Gating Differences between Ca(2+) versus Ba(2+)

Glutamate scanning mutagenesis was used to assess the role of the calcicludine binding segment in regulating channel permeation and gating using both Ca(2+) and Ba(2+) as charge carriers. As expected, wild-type L-type calcium channels had a Ba(2+) conductance ~2× that in Ca(2+) (G(Ba)/G(Ca) = 2) and...

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Bibliografische gegevens
Hoofdauteurs: Li, Zhe, Wang, Xianming, Gao, Guofeng, Qu, Dongmei, Yu, Buwei, Huang, Congxin, Elmslie, Keith S., Peterson, Blaise Z.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704197/
https://ncbi.nlm.nih.gov/pubmed/20098982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-009-9221-1
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