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The Role of Flexibility in the Rational Design of Modularly Assembled Ligands Targeting the RNAs that Cause the Myotonic Dystrophies

Modularly assembled ligands were designed to target the RNAs that cause two currently untreatable neuromuscular disorders, myotonic dystrophy types 1 (DM1) and 2 (DM2). DM1 is caused by an expanded repeating sequence of CUG, and DM2 is caused by expanded CCUG repeats. Both are present in non-coding...

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書誌詳細
主要な著者: Disney, Matthew D., Lee, Melissa M., Pushechnikov, Alexei, Childs-Disney, Jessica L.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848078/
https://ncbi.nlm.nih.gov/pubmed/20058255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200900716
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